Andrew Marderstein

Research Fellow at Memorial Sloan Kettering Cancer Center

Palo Alto, California, United States
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Summary

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Andrew Marderstein is a computational human geneticist and research fellow with a decade of experience translating human genetics and multi-omic data into mechanistic insights and drug discovery leads. Currently at Memorial Sloan Kettering after a postdoc at Stanford and a PhD from Cornell/Weill, he combines statistical genetics, deep learning, and single-cell multi-omics to predict cell-type-specific regulatory effects and uncover chromatin-driven disease mechanisms. His work contributed to a Nature paper linking reshaped chromatin landscapes to clinical features of Down Syndrome and longstanding collaborations with industry (Pfizer, Third Rock Ventures) underline his translational focus. He has repeatedly built and applied novel methods—from vQTLs and GxE to single-cell regulatory models—to prioritize therapeutic targets and predict patient response. Based in Palo Alto, he pairs rigorous computational methods with consortium-scale leadership experience in projects like IGVF, bringing both academic depth and practical impact to precision medicine.
code10 years of coding experience
job2 years of employment as a software developer
bookDoctor of Philosophy - PhD, Computational Biology & Medicine (CBM), Doctor of Philosophy - PhD, Computational Biology & Medicine (CBM) at Weill Cornell Graduate School of Medical Sciences
bookBachelor of Science (BS), Biostatistics (Statistical Genomics concentration), Biological Sciences Minor, Bachelor of Science (BS), Biostatistics (Statistical Genomics concentration), Biological Sciences Minor at Cornell University
bookPostdoctoral Fellow - Computational Genomics, Postdoctoral Fellow - Computational Genomics at Stanford University
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6questions
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Github Skills (18)

markdown9
jekyll-theme9
jekyll9
html8
github-pages8
csv6
gam6
database6
cluster-computing6
bash6
forloop6
python6
bioinformatics5
nextflow4
tsne4

Programming languages (5)

RSCSSJavaScriptNextflowJupyter Notebook

Github contributions (5)

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drewmard/drewmard.github.io

Apr 2021 - Jul 2026

Github Pages template for academic personal websites, forked from mmistakes/minimal-mistakes
Contributions:132 pushes in 5 years 4 months
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drewmard/druggene

Jan 2021 - Jun 2021

Contributions:13 commits, 8 pushes in 4 months
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Andrew Marderstein - Research Fellow at Memorial Sloan Kettering Cancer Center