Henri Palacci
Research Engineer - Member Of The Technical Staff at D. E. Shaw Research
New York City Metropolitan Area United States
Summary
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Senior🎓
Top SchoolHenri Palacci is a research engineer and ML leader specializing in large language models and their application to drug discovery, currently leading LLM-focused applied research at D. E. Shaw Research. He built and scaled ML and software teams from seed to post-Series A as head of ML & SWE at Anagenex and previously co-founded Poisson.AI, an ML consultancy delivering predictive models across chemistry and healthcare. With a PhD in Biophysics & Machine Learning from Columbia and advanced degrees in statistics and applied math from ENSAE and École Polytechnique, he blends deep academic rigor with product-focused engineering. His background also includes a decade leading quantitative trading teams and managing multi-billion dollar derivatives portfolios, bringing uncommon expertise in production-grade infrastructure, distributed training, and high-stakes decision systems. Notably, he helped train early protein LLMs and developed parallel training infrastructure and energy-based generative models for proteins, bridging foundational research and practical drug discovery use cases. Based in the New York metro area, he combines startup grit, research depth, and institutional-scale engineering experience.
11 years of coding experience
9 years of employment as a software developer
Master’s Degree, Statistics, Master’s Degree, Statistics at ENSAE ParisMaster of Science (M.S.), Applied Mathematics, Master of Science (M.S.), Applied Mathematics at École PolytechniqueDoctor of Philosophy - PhD, Biophysics & Machine Learning, Doctor of Philosophy - PhD, Biophysics & Machine Learning at Columbia University
English, French
Github Skills (98)
webapp10
python9
nyc9
reproducible-research9
experiment-manager9
julia8
mta8
statistics8
rendering8
bayesian-inference8
mcmc8
postgresql8
machine-learning8
amazon-web-services8
bayesian8
Programming languages (8)
Github contributions (5)
henripal/sgld
Jan 2018 - Feb 2019
Contributions:13 commits, 13 pushes, 1 branch in 1 year 1 month
henripal/henripal.github.io
Sep 2015 - Oct 2023
Contributions:118 pushes, 2 branches in 8 years 1 month
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